pulmonary scintiscan findings in sulfur mustard injured patients suspected for gastroesophageal reflux; a descriptive cross-sectional study

Authors

ali ghazvini chemical injuries research center, baqiyatallah university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (baqiyatallah university of medical sciences)

ashraf karbasi baqiyatallah research center of gastroenterology and hepatology, baqiyatallah university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (baqiyatallah university of medical sciences)

amin saburi health research center, baqiyatallah university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (baqiyatallah university of medical sciences)

rasoul aliannejad chemical injuries research center, baqiyatallah university of medical sciences, tehran, iranسازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (baqiyatallah university of medical sciences)

abstract

background:gastroesophageal reflux disease (gerd) prevalence in patients with sulfur mustard (sm)-induced bronchiolitis obliterans (bo) is higher than exposed cases with mild lung injuries. in this study, we aimed to evaluate the prevalence of microaspirations using nuclear scintiscan among bo patients with sm exposure. methods: this was a prospective cross-sectional study conducted on patients with sm-induced bo and pulmonary symptom exacerbation referred to the baqiyatallah hospital, tehran, iran during the year 2009. following the endoscopy-based diagnosis of gerd by a gastroenterologist, anti-reflux medications were withdrawn for 72 hours and then the patients underwent nuclear scintigraphy scan following 12 hour ingestion of fat containing food as radionuclide dinner. high resolution computed tomography (hrct), spirometry and bronchoscopy were also performed for all patients. results: in this study, 39 patients (94.9% men) with mean (± sd) age of 45.1 ± 6.2 years were enrolled. the most common clinical complaints of the patients were thick sputum (97.4%) and dyspepsia (94.7%), followed by chest tightness (89.7%), nocturnal cough (82.1%), and nocturnal dyspnea (66.7%). in hrct, air-trapping was the most common pulmonary finding (92.1%). in spirometry, mean (±sd) fev1 and fev1/fvc were 52.7 ± 22.4% and 70.4 ± 13.9%, respectively. in bronchoscopy, the most common finding was airway remodeling (62.2%), followed by false vocal cord hypertrophy (24.3%). in scintigraphic imaging, only 1 patient had a remarkable finding, in whom, the radionuclide material was seen in the pharynx (proximal gerd), but did not produce marked microaspiration of gastric substances into the airways. conclusion:although previous reports demonstrated high prevalence of gerd and microaspiration in patients with sm-induced bo, we did not find remarkable evidence for microaspiration in scintiscan in patients included in this study.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Pulmonary Scintiscan Findings in Sulfur Mustard Injured Patients Suspected for Gastroesophageal Reflux; a Descriptive Cross-Sectional Study

Background:Gastroesophageal reflux disease (GERD) prevalence in patients with sulfur mustard (SM)-induced bronchiolitis obliterans (BO) is higher than exposed cases with mild lung injuries. In this study, we aimed to evaluate the prevalence of microaspirations using nuclear scintiscan among BO patients with SM exposure. Methods: This was a prospective cross-sectional study conducted on patient...

full text

Association between chronic obstructive pulmonary disease and gastroesophageal reflux disease: a national cross-sectional cohort study

BACKGROUND Gastroesophageal reflux disease (GERD) is one of the most common causes of chronic cough and a potential risk factor for exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors of GERD in patients with COPD and association between GERD and COPD exacerbation. METHODS Data were collected from the National ...

full text

The Role of Oxidative Stress in Severity of Obstructive Pulmonary Complications in Sputum of Sulfur Mustard-Injured Patients

Background: Sulfur mustard (SM) is a strong bifunctional alkylating agent that causes delayed complications in organs such as lung. Oxidative stress plays a pivotal role in the pathogenesis and progression of many pulmonary diseases. The aim of this study was to investigate the oxidative stress in sputum of SM exposed patients with mild, moderate and severe pulmonary dysfunction and assessing t...

full text

EVALUATION OF 17 PATIENTS SEVERELY INJURED WITH SULFUR MUSTARD

In this article, we evaluated 17 Iranian soldiers who were exposed to mustard gas utilized by the Iraqi forces in the war fronts. Their clinical symptoms and signs, laboratory tests, and other parameters were carefully assessed, an attempt was made to identify a finding of prognostic significance, and patients who recovered from the acute phase were followed to determine possible long-term...

full text

Moral distress level in nurses and physicians caring for patients with COVID-19: A cross-sectional descriptive study in 2020

Abstract Introduction: Due to the increasing number of COVID-19 in the world and the prevalence of the second peak of disease in Iran, we are witnessing the death of many of our compatriots in the country's hospitals every day. Meanwhile, the medical staff of hospitals, especially doctors and nurses, have the most conflicts with patients with COVID-19. Considering the very important issue of mo...

full text

Reflux esophagitis in war-related sulfur mustard lung disease

  Background: Sulfur mustard (SM) has acute and chronic effects on skin and mucosal surfaces. The aim of the study was to evaluate the frequency of esophagitis in a historical cohort of veterans who had been exposed to SM in Iran-Iraq war nearly 25 years ago.   Methods : One hundred two veterans with dyspepsia and/or heartburn underwent esophago-gastro-duodenoscopy. Of them, 52 cases had been e...

full text

My Resources

Save resource for easier access later


Journal title:
asia pacific journal of medical toxicology

جلد ۴، شماره ۴، صفحات ۱۳۴-۱۳۸

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023